Chitkara D K, Manners T, Chapman F, Stoddart M G, Hill D, Jenkins D
Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne.
Br J Ophthalmol. 1994 Oct;78(10):772-4. doi: 10.1136/bjo.78.10.772.
Eighty patients undergoing routine standardised extracapsular cataract surgery with lens implantation were divided randomly into two groups in a prospective double blind study comparing effects of preoperative norfloxacin eyedrops with placebo on bacterial contamination of anterior chamber aspirates after surgery. Pathogenic organisms were identified from 19 (24%) of the aspirates. The most commonly isolated organisms were coagulase negative Staphylococcus species. There was no statistical difference between the norfloxacin treated and placebo groups. This study demonstrates that routine use of topical preoperative antibiotics to eliminate the entry of bacteria into the eye during surgery is debatable.
在一项前瞻性双盲研究中，80例行常规标准化囊外白内障摘除联合晶状体植入术的患者被随机分为两组，比较术前使用诺氟沙星滴眼液与安慰剂对术后前房穿刺液细菌污染的影响。从19份（24%）穿刺液中鉴定出致病微生物。最常分离出的微生物是凝固酶阴性葡萄球菌。诺氟沙星治疗组和安慰剂组之间无统计学差异。这项研究表明，术前常规使用局部抗生素以消除手术期间细菌进入眼内的做法存在争议。
