Eastman C I, Stewart K T, Mahoney M P, Liu L, Fogg L F
Biological Rhythms Research Laboratory, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612-3864.
Sleep. 1994 Sep;17(6):535-43. doi: 10.1093/sleep/17.6.535.
We compared the contributions of bright light during the night shift and dark goggles during daylight for phase shifting the circadian rhythm of temperature to realign with a 12-hour shift of sleep. After 10 baseline days there were 8 night-work/day-sleep days. Temperature was continuously recorded from 50 subjects. There were four groups in a 2 x 2 design: light (bright, dim), goggles (yes, no). Subjects were exposed to bright light (about 5,000 lux) for 6 hours on the first 2 night shifts. Dim light was < 500 lux. Both bright light and goggles were significant factors for producing circadian rhythm phase shifts. The combination of bright light plus goggles was the most effective, whereas the combination of dim light and no goggles was the least effective. The temperature rhythm either phase advanced or phase delayed when it aligned with daytime sleep. However, when subjects did not have goggles only phase advances occurred. Goggles were necessary for producing phase delays. The most likely explanation is that daylight during the travel-home window after a night shift inhibits phase-delay shifts, and goggles can prevent this inhibition. Larger temperature-rhythm phase shifts were associated with better subjective daytime sleep, less subjective fatigue and better mood.
我们比较了夜班期间强光照射和白天佩戴深色护目镜对体温昼夜节律进行相位调整，以使其与12小时睡眠班次重新对齐的作用。在10天的基线期后，有8个夜班/白天睡眠日。连续记录了50名受试者的体温。采用2×2设计分为四组：光照（强光、弱光）、护目镜（佩戴、不佩戴）。在前两个夜班期间，受试者接受6小时的强光照射（约5000勒克斯）。弱光<500勒克斯。强光和护目镜都是产生昼夜节律相位变化的重要因素。强光加护目镜的组合最有效，而弱光且不佩戴护目镜的组合最无效。当体温节律与白天睡眠对齐时，要么相位提前，要么相位延迟。然而，当受试者不佩戴护目镜时，仅出现相位提前。产生相位延迟需要佩戴护目镜。最可能的解释是，夜班后回家途中的日光会抑制相位延迟变化，而护目镜可以防止这种抑制。较大的体温节律相位变化与更好的白天主观睡眠、更少的主观疲劳和更好的情绪相关。
