Bujia J, Zietz C, Randolph P, Wilmes E, Gürtler L
Department of Otorhinolaryngology, Klinikum Grosshadern, Munich, Germany.
Eur Arch Otorhinolaryngol. 1994;251(6):347-9. doi: 10.1007/BF00171543.
Human immunodeficiency virus (HIV) infections are mainly transferred by blood, semen or organ transplantations. Since allogenic transplants have an established place in reconstructive surgery, the possibility of transferring HIV with such transplants has been a subject of much concern. Postmortem cartilage samples were obtained from eight HIV-infected patients and examined using the polymerase chain reaction in order to detect proviral HIV-1 DNA (gag, pol, env). Blood, brain and spleen samples were also obtained and used as positive controls. Results showed that no cartilage sample contained any HIV-DNA, whereas proviral sequences were clearly demonstrated in perichondrium from six patients. These findings indicate that HIV is not present in cartilage of HIV-infected patients, making HIV transmission through cartilage grafting improbable when transplants from HIV-negative donors are used.
人类免疫缺陷病毒（HIV）感染主要通过血液、精液或器官移植传播。由于同种异体移植在整形手术中已占有一席之地，通过此类移植传播HIV的可能性一直备受关注。从八名HIV感染患者身上获取了死后软骨样本，并使用聚合酶链反应进行检测，以检测前病毒HIV-1 DNA（gag、pol、env）。还获取了血液、大脑和脾脏样本并用作阳性对照。结果显示，没有软骨样本含有任何HIV-DNA，而在六名患者的软骨膜中清楚地检测到了前病毒序列。这些发现表明，HIV感染患者的软骨中不存在HIV，因此当使用来自HIV阴性供体的移植物时，通过软骨移植传播HIV的可能性不大。
