Bujía J, Pitzke P, Wilmes E, Hammer C, Gürtler L
Department of Otorhinolaryngology, Ludwig Maximilians University Munich, Germany.
Eur Arch Otorhinolaryngol. 1993;250(1):55-8. doi: 10.1007/BF00176950.
Allogeneic cartilage represents an important source of tissue for reconstructive surgery in the head and neck. The use of allografts is now being discussed because of the possible transmission of the human immunodeficiency virus (HIV). The receptor for HIV in most cell types is the CD-4 molecule. Since cartilage is a popular homograft source, the purpose of this study was to investigate the presence of CD-4 molecules on cartilage tissue as detected with an immunoperoxidase staining and immunofluorescence flow cytometric analysis using a monoclonal antibody. Our results indicate clearly the absence of the HIV receptor on human cartilage tissue. We have concluded therefore that normal cartilage tissue cannot be infected by HIV, at least not through a CD-4-dependent mechanism.
同种异体软骨是头颈重建手术重要的组织来源。由于可能传播人类免疫缺陷病毒（HIV），目前正在讨论同种异体移植物的使用。大多数细胞类型中HIV的受体是CD-4分子。由于软骨是常用的同种异体移植来源，本研究的目的是使用单克隆抗体，通过免疫过氧化物酶染色和免疫荧光流式细胞术分析，研究软骨组织上CD-4分子的存在情况。我们的结果清楚地表明人类软骨组织上不存在HIV受体。因此，我们得出结论，正常软骨组织不能被HIV感染，至少不能通过依赖CD-4的机制感染。
