Wilkinson A E, Rodin P
Br J Vener Dis. 1976 Aug;52(4):219-23. doi: 10.1136/sti.52.4.219.
IgM-FTA tests have been carried out on 209 sera from 169 patients with treated or untreated syphilis at various stages and on 128 sera from 109 patients, born in areas where yaws is or was prevalent, with treated or untreated latent treponemal disease. IgM anti-treponemal antibody was found in virtually all cases of untreated early or early latent syphilis but in only 23 per cent. of sera from patients with untreated late latent syphilis. After treatment the antibody usually disappeared within one year, but it persisted in a minority of patients, including some treated for late symptomatic or congenital syphilis. Except in isolated cases there was no clinical evidence to suggest continued disease activity, although a third of the patient in whom the antibody persisted for more than 2 years after treatment were noted to be homosexuals. The test may assist in differentiating untreated early latent from late latent syphilis.
对169例处于不同阶段的梅毒患者（已治疗或未治疗）的209份血清，以及109例出生于雅司病曾经或仍然流行地区、患有已治疗或未治疗的潜伏性梅毒螺旋体病患者的128份血清进行了IgM - FTA检测。在几乎所有未经治疗的早期或早期潜伏梅毒病例中均发现了IgM抗梅毒螺旋体抗体，但在未经治疗的晚期潜伏梅毒患者的血清中仅23%检测到该抗体。治疗后，抗体通常在一年内消失，但仍有少数患者持续存在，包括一些接受过晚期症状性或先天性梅毒治疗的患者。除个别病例外，没有临床证据表明疾病仍在活动，尽管在治疗后抗体持续超过2年的患者中有三分之一被发现是同性恋者。该检测可能有助于区分未经治疗的早期潜伏梅毒和晚期潜伏梅毒。
