Everall I P, Glass J D, McArthur J, Spargo E, Lantos P
Department of Neuropathology, Institute of Psychiatry, London, UK.
Acta Neuropathol. 1994;88(6):538-44. doi: 10.1007/BF00296490.
Human immune deficiency virus (HIV) disease may be associated, neuropathologically, with significant neuronal loss and clinically with a severe dementia. However, the significance of neuronal loss in the development of dementia has not been established. In this study we have undertaken a stereological determination of the neuronal numerical density and neuronal volumes in post mortem tissue from the superior frontal and superior temporal gyri in 32 patients who died of acquired immune deficiency syndrome (AIDS). All were prospectively clinically characterized, with dementia identified or excluded, and antiretroviral medication documented. This study combines morphometric techniques with prospective clinical assessment of dementia. As previously demonstrated, all patients dying with AIDS showed neuronal loss, but this was not related to the presence of HIV-associated dementia.
人类免疫缺陷病毒（HIV）疾病在神经病理学上可能与显著的神经元丢失有关，在临床上则与严重痴呆相关。然而，神经元丢失在痴呆发展中的意义尚未明确。在本研究中，我们对32例死于获得性免疫缺陷综合征（AIDS）患者的额上回和颞上回死后组织中的神经元数量密度和神经元体积进行了体视学测定。所有患者均进行了前瞻性临床特征描述，确定或排除了痴呆，并记录了抗逆转录病毒药物治疗情况。本研究将形态测量技术与痴呆的前瞻性临床评估相结合。如先前所示，所有死于AIDS的患者均出现神经元丢失，但这与HIV相关痴呆的存在无关。
