Seilhean D, Duyckaerts C, Vazeux R, Bolgert F, Brunet P, Katlama C, Gentilini M, Hauw J J
Laboratoire de Neuropathologie R. Escourolle, INSERM U 360, Association Claude Bernard, Hôpital de la Salpêtrière, Paris, France.
Neurology. 1993 Aug;43(8):1492-9. doi: 10.1212/wnl.43.8.1492.
We performed a postmortem morphometric study in six AIDS patients and six controls to determine if a neocortical neuronal loss occurs in HIV-1-associated cognitive/motor complex. Patients were selected during a prospective study including psychometric evaluation and neuroimaging, and none had focal lesions. Two had HIV-1-associated myelopathy with mild cognitive impairment, and four had HIV-1-associated dementia complex. Planimetry did not show any cerebral atrophy. Cortical thickness, mean neuronal size, and mean neuronal densities in Brodmann's areas 4, 9, and 40 were not statistically different in patients and controls. There were no significant changes in neuronal densities of columnar and laminar samples, indicating that there was neither global nor selective neuronal loss. HIV-1-associated cognitive/motor complex is not necessarily related to neocortical neuronal loss, but could be due to subcortical lesions or metabolic dysfunction.
我们对6例艾滋病患者和6例对照者进行了尸检形态学研究，以确定在HIV-1相关的认知/运动复合体中是否发生新皮质神经元丢失。患者是在一项包括心理测量评估和神经影像学检查的前瞻性研究中入选的，均无局灶性病变。2例患有HIV-1相关脊髓病并伴有轻度认知障碍，4例患有HIV-1相关痴呆复合体。平面测量未显示任何脑萎缩。患者和对照者在布罗德曼第4、9和40区的皮质厚度、平均神经元大小和平均神经元密度无统计学差异。柱状和层状样本的神经元密度无显著变化，表明既没有整体的也没有选择性的神经元丢失。HIV-1相关的认知/运动复合体不一定与新皮质神经元丢失有关，而可能是由于皮质下病变或代谢功能障碍所致。
