Ragno S, Morris C J, Coumbe A, Mapp P I, Colston M J, Blake D R, Winrow V R
ARC Bone and Joint Research Unit, London Hospital Medical College, United Kingdom.
Ann Rheum Dis. 1995 Jan;54(1):59-65. doi: 10.1136/ard.54.1.59.
To investigate the time course of a monoarthritis induced with the purified protein derivative of tuberculin (PPD) or a recombinant 65 kDa heat shock protein (rhsp65) in two different strains of sensitised rats.
Wistar and Lewis rats, sensitised with heat killed Mycobacterium tuberculosis in oil, were challenged intraarticularly with PPD or rhsp65 and monitored for six weeks. Inflammation was assessed by joint swelling, histology, and radiographic studies.
Sensitised Lewis rats injected with PPD or rhsp65 showed a chronic response with recurrent spontaneous flares, while Wistar rats showed one inflammatory episode.
The Wistar strain response to PPD resembles a transient reactive arthritis, while the response of the Lewis strain mimics the relapsing nature of rheumatoid synovitis, providing an interesting model to determine dominant immunopathogenic mechanisms.
研究在两种不同品系的致敏大鼠中，用结核菌素纯蛋白衍生物（PPD）或重组65 kDa热休克蛋白（rhsp65）诱导单关节炎的时间进程。
用热灭活的结核分枝杆菌油剂致敏的Wistar和Lewis大鼠，通过关节内注射PPD或rhsp65进行攻击，并监测六周。通过关节肿胀、组织学和放射学研究评估炎症。
注射PPD或rhsp65的致敏Lewis大鼠表现出慢性反应，伴有反复的自发发作，而Wistar大鼠表现出一次炎症发作。
Wistar品系对PPD的反应类似于短暂性反应性关节炎，而Lewis品系的反应模仿类风湿性滑膜炎的复发性质，为确定主要的免疫致病机制提供了一个有趣的模型。
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