Renauld J C, Kermouni A, Vink A, Louahed J, Van Snick J
Ludwig Institute for Cancer Research, Catholic University of Louvain, Brussels, Belgium.
J Leukoc Biol. 1995 Mar;57(3):353-60. doi: 10.1002/jlb.57.3.353.
Interleukin-9 (IL-9) is a multifunctional cytokine produced by activated TH2 clones in vitro and during TH2-like T cell responses in vivo. The IL-9 receptor is a member of the hemopoietin receptor superfamily and interacts with the gamma chain of the IL-2 receptor for signal transduction. Various observations indicate that IL-9 is actively involved in mast cell responses by inducing the proliferation and differentiation of these cells. The role of IL-9 in T cell responses is less clear. Although freshly isolated normal T cells do not respond to IL-9, this cytokine induces the proliferation of murine T cell lymphomas in vitro and in vivo overexpression of IL-9 results in the development of thymic lymphomas. In the human, the existence of an IL-9-mediated autocrine loop has been suggested for some malignancies such as Hodgkin's disease. Other potential biological targets for IL-9 include B lymphocytes, hematopoietic progenitors, and immature neuronal cell lines.
白细胞介素-9（IL-9）是一种多功能细胞因子，由体外活化的TH2克隆以及体内类似TH2的T细胞反应过程中产生。IL-9受体是血细胞生成素受体超家族的成员，与IL-2受体的γ链相互作用以进行信号转导。各种观察结果表明，IL-9通过诱导肥大细胞的增殖和分化而积极参与肥大细胞反应。IL-9在T细胞反应中的作用尚不清楚。虽然新鲜分离的正常T细胞对IL-9无反应，但这种细胞因子在体外可诱导鼠T细胞淋巴瘤增殖，且在体内IL-9的过表达会导致胸腺淋巴瘤的发生。在人类中，对于某些恶性肿瘤如霍奇金病，已有人提出存在IL-9介导的自分泌环。IL-9的其他潜在生物学靶点包括B淋巴细胞、造血祖细胞和未成熟神经元细胞系。
