Adlercreutz H, Markkanen H, Watanabe S
Department of Clinical Chemistry, University of Helsinki, Mellahti Hospital, Finland.
Lancet. 1993 Nov 13;342(8881):1209-10. doi: 10.1016/0140-6736(93)92188-y.
A low mortality from prostatic cancer is found in Japanese men consuming a low-fat diet with high content of soy products, a rich source of isoflavonoids. We therefore assayed four isoflavonoids in plasma of 14 Japanese and 14 Finnish men. The geometric mean plasma total individual isoflavonoid levels were 7 to 110 times higher in the Japanese than in the Finnish men. Genistein, a tyrosine kinase inhibitor, occurred in the highest concentration (geometric mean 276 nmol/L). We hypothesise that these high phyto-oestrogen levels may inhibit the growth of prostatic cancer in Japanese men, which may explain the low mortality from prostatic cancer in that country.
在食用低脂且富含大豆制品（异黄酮的丰富来源）饮食的日本男性中，前列腺癌死亡率较低。因此，我们检测了14名日本男性和14名芬兰男性血浆中的四种异黄酮。日本男性血浆中总的个体异黄酮水平几何平均值比芬兰男性高7至110倍。染料木黄酮，一种酪氨酸激酶抑制剂，浓度最高（几何平均值为276纳摩尔/升）。我们推测，这些高植物雌激素水平可能会抑制日本男性前列腺癌的生长，这或许可以解释该国前列腺癌的低死亡率。
