Vågerö D, Leon D
Swedish Institute for Social Research, Stockholm University.
Lancet. 1994 Jan 29;343(8892):260-3. doi: 10.1016/s0140-6736(94)91112-6.
Twins constitute a population with lower than average birth weight for reasons that are not a consequence of social disadvantage. The hypothesis that ischaemic heart disease (IHD) is linked to low birth weight was tested by analysing whether or not 8174 female and 6612 male Swedish twins had a higher mortality compared to the general Swedish population. The association between adult body height and IHD mortality was also analysed in a nested case-control study among monozygotic and dizygotic twins. Ischaemic heart disease mortality was not higher among twins (women: relative risk [RR] 0.99; 95% confidence limits [CL] 0.89-1.10; men: RR 0.85; CL 0.79-0.92). However, the shorter twin in a twin pair was more likely to die of heart disease than the taller (odds ratio [OR] 1.15, CL 1.03-1.25). We suggest that postnatal influences may well be as important as prenatal influences in producing any effect on ischaemic heart disease mortality and that the type of growth retardation in utero experienced by twins may not constitute a risk for ischaemic heart disease in adulthood.
双胞胎出生体重低于平均水平，其原因并非社会劣势所致。通过分析8174名瑞典女性双胞胎和6612名瑞典男性双胞胎的死亡率是否高于瑞典普通人群，对缺血性心脏病（IHD）与低出生体重之间的假说进行了检验。在一项针对同卵双胞胎和异卵双胞胎的巢式病例对照研究中，还分析了成人身高与IHD死亡率之间的关联。双胞胎中缺血性心脏病死亡率并不更高（女性：相对风险[RR] 0.99；95%置信区间[CL] 0.89 - 1.10；男性：RR 0.85；CL 0.79 - 0.92）。然而，双胞胎中较矮的一方死于心脏病的可能性高于较高的一方（优势比[OR] 1.15，CL 1.03 - 1.25）。我们认为，产后影响在对缺血性心脏病死亡率产生任何影响方面可能与产前影响同样重要，而且双胞胎在子宫内经历的生长迟缓类型可能并不构成成年后患缺血性心脏病的风险。
