Pizzolato P
Am J Med Technol. 1976 Nov;42(11):436-40.
Black to brown amorphous to microcrystalline granules are encountered in histologic sections prepared from tissues fixed in formalin having a low pH. This pigment is produced by acid acting upon hemoglobin and is known as formalin pigment or acid hematin. A similar pigment is also observed in sites of bleeding ulcers in areas of acid production such as the stomach. These pigments exhibit many physical and histochemical properties similiar to pigments produced by some animal parasites as in malaria, schistosoma and pulmonary mites. These parasites disintegrate erythrocytes in an unknown manner, and liberate an acid hematin-like pigment which is phagocytized by the reticuloendothelial system. Since formalin pigment can be considered as an artifact, confusion with other pigments can be avoided by the use of neutral buffered formalin for the fixation of tissues.
在由低pH值的福尔马林固定的组织制备的组织学切片中，可以看到黑色至棕色的无定形至微晶颗粒。这种色素是由酸作用于血红蛋白产生的，被称为福尔马林色素或酸性高铁血红素。在产酸区域（如胃）的出血性溃疡部位也观察到类似的色素。这些色素表现出许多物理和组织化学性质，类似于一些动物寄生虫（如疟疾、血吸虫和肺螨）产生的色素。这些寄生虫以未知方式使红细胞解体，并释放出一种类似酸性高铁血红素的色素，该色素被网状内皮系统吞噬。由于福尔马林色素可被视为一种人为产物，因此通过使用中性缓冲福尔马林固定组织可避免与其他色素混淆。
