作为软性内窥镜高水平消毒剂的邻苯二甲醛的院内评估。
In-hospital evaluation of orthophthalaldehyde as a high level disinfectant for flexible endoscopes.
作者信息
Alfa M J, Sitter D L
机构信息
Department of Microbiology, St. Boniface General Hospital, Winnipeg, Manitoba, Canada.
出版信息
J Hosp Infect. 1994 Jan;26(1):15-26. doi: 10.1016/0195-6701(94)90075-2.
Abstract
One hundred endoscopes used for bronchoscopy (30), gastroscopy (35) or colonoscopy (35) were studied to determine the efficiency of a new high level disinfectant, orthophthalaldehyde (OPA). Manual cleaning was the method studied since this would be the least effective and thereby provide the greatest challenge to the 0.5% (w/v) OPA solution. The OPA was convenient and easy to use since it did not have irritating vapours and as it is used directly, does not require dilution. Our study demonstrated that the OPA was stable for up to 14 days despite repeated re-use. The cleaning/disinfection procedure could achieve a > or = 5 LOG10 reduction in bacterial load. This in-hospital evaluation supports the conclusion that OPA is an effective choice as a high level disinfectant for flexible endoscopes.
摘要
研究了用于支气管镜检查（30 例）、胃镜检查（35 例）或结肠镜检查（35 例）的 100 条内窥镜，以确定新型高效消毒剂邻苯二甲醛（OPA）的效能。采用手工清洗作为研究方法，因为这是最无效的方法，从而对 0.5%（w/v）的 OPA 溶液构成最大挑战。OPA 使用方便，因为它没有刺激性蒸汽，而且由于直接使用，不需要稀释。我们的研究表明，尽管反复重复使用，OPA 可稳定保存长达 14 天。清洗/消毒程序可使细菌载量减少≥5 个对数 10。这项院内评估支持以下结论：OPA 作为软性内窥镜的高效消毒剂是一种有效的选择。
相似文献
1
In-hospital evaluation of orthophthalaldehyde as a high level disinfectant for flexible endoscopes.作为软性内窥镜高水平消毒剂的邻苯二甲醛的院内评估。
J Hosp Infect. 1994 Jan;26(1):15-26. doi: 10.1016/0195-6701(94)90075-2.
2
3
Microbial bioburden in endoscope reprocessing and an in-use evaluation of the high-level disinfection capabilities of Cidex PA.内窥镜再处理中的微生物生物负荷以及戊二醛（Cidex PA）高水平消毒能力的使用中评估。
Gastroenterol Nurs. 1999 Mar-Apr;22(2):63-8. doi: 10.1097/00001610-199903000-00007.
4
Sporicidal activity of disinfectants as one possible cause for bacteria in patient-ready endoscopes.消毒剂的杀孢子活性可能是患者可用内窥镜中存在细菌的一个原因。
Gastroenterol Nurs. 2007 Jul-Aug;30(4):285-90. doi: 10.1097/01.SGA.0000287201.98483.43.
5
Longitudinal assessment of reprocessing effectiveness for colonoscopes and gastroscopes: Results of visual inspections, biochemical markers, and microbial cultures.结肠镜和胃镜再处理效果的纵向评估：视觉检查、生化标志物及微生物培养结果
Am J Infect Control. 2017 Feb 1;45(2):e26-e33. doi: 10.1016/j.ajic.2016.10.017.
6
Worst-case soiling levels for patient-used flexible endoscopes before and after cleaning.患者使用的软性内窥镜清洁前后的最坏污染水平。
Am J Infect Control. 1999 Oct;27(5):392-401. doi: 10.1016/s0196-6553(99)70004-0.
7
Persistent contamination on colonoscopes and gastroscopes detected by biologic cultures and rapid indicators despite reprocessing performed in accordance with guidelines.尽管按照指南进行了再处理，但通过生物培养和快速指标检测发现结肠镜和胃镜存在持续污染。
Am J Infect Control. 2015 Aug;43(8):794-801. doi: 10.1016/j.ajic.2015.03.003.
8
EVOTECH endoscope cleaner and reprocessor (ECR) simulated-use and clinical-use evaluation of cleaning efficacy.易伟特内镜清洗消毒机（ECR）模拟使用和临床使用清洗效果评价。
BMC Infect Dis. 2010 Jul 9;10:200. doi: 10.1186/1471-2334-10-200.
9
Enteroviruses, endoscopy and infection control: an applied study.肠道病毒、内窥镜检查与感染控制：一项应用研究。
J Hosp Infect. 1994 May;27(1):61-7. doi: 10.1016/0195-6701(94)90069-8.
10
Disinfection of rigid nasal endoscopes following in vitro contamination with Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, and Haemophilus influenzae.刚性鼻内镜在体外污染金黄色葡萄球菌、肺炎链球菌、铜绿假单胞菌和流感嗜血杆菌后的消毒。
JAMA Otolaryngol Head Neck Surg. 2013 Jun;139(6):574-8. doi: 10.1001/jamaoto.2013.3016.
引用本文的文献
1
Determination of o-phthalaldehyde for dose verification of the clinical disinfectant by fluorescent sequential injection analysis.荧光顺序注射分析测定邻苯二醛对临床消毒剂剂量验证。
Anal Sci. 2023 Dec;39(12):2007-2017. doi: 10.1007/s44211-023-00415-4. Epub 2023 Aug 26.
2
An Electrochemical -Phthalaldehyde Sensor Using a Modified Disposable Screen-Printed Electrode with Polyacrylate Hydrogel for Concentration Verification of Clinical Disinfectant.一种使用改性一次性丝网印刷电极和聚丙烯酸水凝胶的电化学-邻苯二醛传感器，用于临床消毒剂浓度验证。
Biosensors (Basel). 2023 Apr 17;13(4):485. doi: 10.3390/bios13040485.
3
The effect of disinfectants and antiseptics on co- and cross-selection of resistance to antibiotics in aquatic environments and wastewater treatment plants.消毒剂和防腐剂对水生环境及污水处理厂中抗生素耐药性的共同选择和交叉选择的影响。
Front Microbiol. 2022 Dec 13;13:1050558. doi: 10.3389/fmicb.2022.1050558. eCollection 2022.
4
Prospective comparative study between the effect of CIDEX OPA and STERRAD NX on the durability of digital flexible ureteroscope.前瞻性对比研究 CIDEX OPA 和 STERRAD NX 对数字式软性输尿管镜耐用性的影响。
World J Urol. 2020 Mar;38(3):775-781. doi: 10.1007/s00345-019-02800-z. Epub 2019 May 13.
5
An exception to the rule "no association between antibiotic resistance and decreased disinfectant microbicidal efficacy": Orthophthalaldehyde (OPA) and isolated from ICU and paraplegic patients.“抗生素耐药性与消毒剂杀菌效果降低之间无关联”这一规则的一个例外情况：从重症监护病房（ICU）和截瘫患者中分离出的邻苯二甲醛（OPA） 。 （注：原文表述不太完整和清晰，翻译可能会稍显生硬，但尽量忠实于原文）
J Prev Med Hyg. 2017 Mar;58(1):E42-E47.
6
Residual bioburden in reprocessed side-view endoscopes used for endoscopic retrograde cholangiopancreatography (ERCP).用于内镜逆行胰胆管造影术（ERCP）的再处理侧视内镜中的残留生物负载。
Endosc Int Open. 2013 Dec;1(1):12-6. doi: 10.1055/s-0033-1359234.
7
Is peracetic acid suitable for the cleaning step of reprocessing flexible endoscopes?过氧乙酸是否适用于软式内镜再处理的清洗步骤？
World J Gastrointest Endosc. 2014 Sep 16;6(9):390-406. doi: 10.4253/wjge.v6.i9.390.
8
A review of current disinfectants for gastrointestinal endoscopic reprocessing.当前用于胃肠内镜再处理的消毒剂综述。
Clin Endosc. 2013 Jul;46(4):337-41. doi: 10.5946/ce.2013.46.4.337. Epub 2013 Jul 31.
9
Current and emergent strategies for disinfection of hospital environments.医院环境消毒的当前及新出现策略。
J Antimicrob Chemother. 2013 Dec;68(12):2718-32. doi: 10.1093/jac/dkt281. Epub 2013 Jul 18.
10
Use of flexible endoscopes for NOTES: sterilization or high-level disinfection?NOTES 中使用软性内镜：灭菌还是高水平消毒？
Surg Endosc. 2010 Jul;24(7):1581-8. doi: 10.1007/s00464-009-0815-6. Epub 2009 Dec 24.
本文引用的文献
1
Pseudomonas aeruginosa sepsis following retrograde cholangiopancreatography (ERCP).逆行胰胆管造影术（ERCP）后发生铜绿假单胞菌败血症。
Dig Dis Sci. 1982 Feb;27(2):169-70. doi: 10.1007/BF01311712.
2
Endoscopic transmission of hepatitis B virus.乙型肝炎病毒的内镜传播
Gut. 1983 Feb;24(2):171-4. doi: 10.1136/gut.24.2.171.
3
Mycobacterial cross-contamination of bronchoscopy specimens.支气管镜检查标本的分枝杆菌交叉污染
Am Rev Respir Dis. 1982 Dec;126(6):1095-7. doi: 10.1164/arrd.1982.126.6.1095.
4
Salmonellosis infection transmitted by fibreoptic endoscopes.由纤维内窥镜传播的沙门氏菌感染。
Lancet. 1982 Oct 16;2(8303):864-6. doi: 10.1016/s0140-6736(82)90821-2.
5
Pseudomonas infection of the biliary system resulting from use of a contaminated endoscope.因使用受污染的内窥镜导致的胆道系统假单胞菌感染。
Gastroenterology. 1987 Mar;92(3):759-63. doi: 10.1016/0016-5085(87)90029-1.
6
Salmonella newport infections transmitted by fiberoptic colonoscopy.通过纤维结肠镜检查传播的纽波特沙门氏菌感染。
Gastrointest Endosc. 1987 Apr;33(2):84-7. doi: 10.1016/s0016-5107(87)71515-6.
7
Cleaning and disinfection of equipment for gastrointestinal flexible endoscopy: interim recommendations of a Working Party of the British Society of Gastroenterology.胃肠道软性内镜设备的清洁与消毒：英国胃肠病学会工作组的临时建议
Gut. 1988 Aug;29(8):1134-51. doi: 10.1136/gut.29.8.1134.
8
Disinfection of gastrointestinal fibrescopes: an evaluation of the Pauldrach Endocleaner, and various chemical agents.
J Hosp Infect. 1985 Dec;6(4):379-88. doi: 10.1016/0195-6701(85)90054-4.
9
Decontamination of fibreoptic endoscopes.纤维光学内窥镜的去污
J Hosp Infect. 1985 Dec;6(4):363-8. doi: 10.1016/0195-6701(85)90052-0.
10
An 'outbreak' of pulmonary pseudoinfection by Serratia marcescens.粘质沙雷氏菌引起的肺部假性感染“暴发”。
J Hosp Infect. 1985 Jun;6(2):218-20. doi: 10.1016/s0195-6701(85)80101-8.
Zotero 插件