Kimura Y, Tojima H, Fukase S, Takeda K
Department of Otolaryngology, Yamagata University School of Medicine, Japan.
Acta Otolaryngol Suppl. 1994;511:192-5. doi: 10.3109/00016489409128330.
Sizofilan (SPG), a simple glucan produced in a culture medium by Schizophyllum commune Feries, was used as an assistant immunotherapy in 15 patients with head and neck cancer. The cumulative 5-year survival rate was 86.7% in the SPG-treated group and 73.4% in the control group. Immunological parameters showed that the SPG group quickly recovered the cellular immunity damaged by radiation, chemotherapy and surgical procedure. SPG was found to be effective as an assistant immunotherapeutic agent in the treatment of head and neck.
裂褶菌聚糖（SPG）是裂褶菌在培养基中产生的一种简单葡聚糖，被用于15例头颈癌患者的辅助免疫治疗。SPG治疗组的累积5年生存率为86.7%，对照组为73.4%。免疫参数显示，SPG组能迅速恢复因放疗、化疗和手术而受损的细胞免疫。结果发现，SPG作为辅助免疫治疗剂对头颈癌治疗有效。
