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细胞因子诱导的人滑膜细胞可溶性细胞间黏附分子-1对滑膜细胞-淋巴细胞黏附的影响。

Effect of cytokine-induced soluble ICAM-1 from human synovial cells on synovial cell-lymphocyte adhesion.

作者信息

Shingu M, Hashimoto M, Ezaki I, Nobunaga M

机构信息

Department of Clinical Immunology, Kyushu University, Beppu, Japan.

出版信息

Clin Exp Immunol. 1994 Oct;98(1):46-51. doi: 10.1111/j.1365-2249.1994.tb06605.x.

DOI:10.1111/j.1365-2249.1994.tb06605.x
PMID:7923883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1534171/
Abstract

The present study was designed to establish (i) the effects of cytokines on soluble ICAM-1 (sICAM-1) production by human synovial cells (SC) and ICAM-1 expression on these cells, and (ii) the effects of sICAM-1 on lymphocyte-SC adhesion. sICAM-1 production was enhanced in parallel with ICAM-1 expression by IL-1 beta, TNF-alpha and IFN-gamma. IL-4 showed no effects on ICAM-1 expression. In contrast with the transient elevation of cell-associated ICAM-1 by IL-1 beta, which peaked 36 h after stimulation and declined thereafter, sICAM-1 continued to accumulate in culture supernatants even after 48 h. Purified sICAM-1 was obtained from a 48 h culture synovial cell supernatant by affinity chromatography using ICAM-1 monoclonal antibody. The purified sICAM-1 significantly inhibited adhesion of lymphocytes and monocytes to cytokine-stimulated synovial cells. These results suggest that sICAM-1 may modulate chronic synovitis by inhibiting ICAM-1-mediated cell-to-cell adhesion.

摘要

本研究旨在确定

（i）细胞因子对人滑膜细胞（SC）可溶性细胞间黏附分子-1（sICAM-1）产生及这些细胞上ICAM-1表达的影响；（ii）sICAM-1对淋巴细胞与滑膜细胞黏附的影响。白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）和干扰素-γ（IFN-γ）可使sICAM-1的产生与ICAM-1的表达同时增强。白细胞介素-4（IL-4）对ICAM-1的表达无影响。与IL-1β引起的细胞相关ICAM-1短暂升高不同（刺激后36小时达到峰值，随后下降），即使在48小时后，sICAM-1仍继续在培养上清液中积累。使用ICAM-1单克隆抗体通过亲和层析从48小时培养的滑膜细胞上清液中获得纯化的sICAM-1。纯化的sICAM-1显著抑制淋巴细胞和单核细胞与细胞因子刺激的滑膜细胞的黏附。这些结果表明，sICAM-1可能通过抑制ICAM-1介导的细胞间黏附来调节慢性滑膜炎。

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