小鼠小肠中乳酸杆菌对胆汁酸的去结合作用。
Deconjugation of bile acids by lactobacilli in the mouse small bowel.
作者信息
Tannock G W, Tangerman A, Van Schaik A, McConnell M A
机构信息
Department of Microbiology, University of Otago, Dunedin, New Zealand.
出版信息
Appl Environ Microbiol. 1994 Sep;60(9):3419-20. doi: 10.1128/aem.60.9.3419-3420.1994.
Abstract
Conjugated and unconjugated bile acid concentrations in the small bowel contents and portal serum samples collected from mice with and without lactobacilli (RLFL and RLF, respectively) as gastrointestinal inhabitants were measured. The major portion of bile acids in the small bowel contents of RLFL mice was unconjugated (67.9%) in contrast to that of RFL animals in which a smaller portion of bile acids was unconjugated (23.5%). This study demonstrated that bile salt hydrolase produced by lactobacilli is active under the conditions prevailing in the proximal small bowels of mice.
摘要
测定了分别以有或无作为胃肠道定居菌的乳酸杆菌（分别为RLFL和RLF）的小鼠为对象所采集的小肠内容物和门静脉血清样本中的结合型和非结合型胆汁酸浓度。与RLF动物（其中较小部分胆汁酸为非结合型，占23.5%）相比，RLFL小鼠小肠内容物中胆汁酸的主要部分为非结合型（67.9%）。本研究表明，乳酸杆菌产生的胆汁盐水解酶在小鼠近端小肠的现有条件下具有活性。
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