Lee K S, Rho Y J, Jang S I, Suh M H, Song J Y
Department of Dermatology, University of Keimyung School of Medicine, Taegu, Korea.
Clin Exp Dermatol. 1994 Jul;19(4):285-8. doi: 10.1111/j.1365-2230.1994.tb01196.x.
Striae distensae are characterized by a thinning of connective tissue stroma to produce linear, atrophic-appearing skin. Excessive adrenocortical activity, genetic factors and inherited defects of connective tissues, etc. are important causative factors in the formation of striae distensae, but the basic aetiology is not known. Total RNA was extracted from skin biopsies of five patients with striae distensae. The expression of genes coding for types I and III procollagen, elastin, fibronectin and beta-actin were studied and compared with those of four sex- and age-matched healthy individuals. The percentages of types I and III procollagen mRNA were 9.9 +/- 2.9% (mean +/- s.d.) and 10.6 +/- 1.6%, respectively, of the corresponding controls. The value for fibronectin mRNA in striae distensae was 7.3 +/- 1.8% of the control. The steady-state ratio fibronectin/type I procollagen mRNAs was 0.12 +/- 0.01 in striae distensae and 0.18 +/- 0.01 in the control. These observations suggest that expression of collagens, elastin and fibronectin genes are apparently decreased, and that there is a marked alteration of fibroblast metabolism, in striae distensae.
膨胀纹的特征是结缔组织基质变薄，形成线状、萎缩样皮肤。肾上腺皮质活动过度、遗传因素以及结缔组织的遗传性缺陷等是膨胀纹形成的重要致病因素，但基本病因尚不清楚。从5例膨胀纹患者的皮肤活检组织中提取总RNA。研究了编码I型和III型前胶原、弹性蛋白、纤连蛋白和β-肌动蛋白的基因表达，并与4名年龄和性别匹配的健康个体进行了比较。I型和III型前胶原mRNA的百分比分别为相应对照的9.9±2.9%（平均值±标准差）和10.6±1.6%。膨胀纹中纤连蛋白mRNA的值为对照的7.3±1.8%。膨胀纹中纤连蛋白/I型前胶原mRNA的稳态比值为0.12±0.01，对照为0.18±0.01。这些观察结果表明，膨胀纹中胶原蛋白、弹性蛋白和纤连蛋白基因的表达明显降低，成纤维细胞代谢存在显著改变。
