恶性间皮瘤或原发性肺癌所致恶性胸腔积液中的转化生长因子-β1（TGF-β1）及β2样活性
Transforming growth factor-beta 1 (TGF-beta 1)- and beta 2-like activities in malignant pleural effusions caused by malignant mesothelioma or primary lung cancer.
作者信息
Maeda J, Ueki N, Ohkawa T, Iwahashi N, Nakano T, Hada T, Higashino K
机构信息
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
出版信息
Clin Exp Immunol. 1994 Nov;98(2):319-22. doi: 10.1111/j.1365-2249.1994.tb06144.x.
Abstract
We investigated the levels of TGF-beta in malignant pleural effusions (MPE) caused by malignant mesothelioma (MESO) or primary lung cancer. TGF-beta levels in MPE caused by MESO were 283.9 +/- 219.2 pm (mean +/- s.d.) and were three to six times higher than those due to primary lung cancers (P < 0.01 or P < 0.05). We also evaluated TGF-beta 1- and beta 2-like activities in MPE using specific polyclonal antibodies. Although TGF-beta 1-like activity could be detected in all cases, TGF-beta 2-like activities were detected in five of seven in MESO and in a few cases with primary lung cancer. These results demonstrate that the levels of total TGF-beta and TGF-beta 2-like activity may be clinically useful to differentiate MESO from primary lung cancer. Our data also suggest that TGF-beta may help further characterize the clinical features of MESO.
摘要
我们研究了恶性间皮瘤（MESO）或原发性肺癌所致恶性胸腔积液（MPE）中转化生长因子-β（TGF-β）的水平。MESO所致MPE中TGF-β水平为283.9±219.2皮摩尔（均值±标准差），比原发性肺癌所致者高3至6倍（P<0.01或P<0.05）。我们还使用特异性多克隆抗体评估了MPE中TGF-β1和β2样活性。虽然在所有病例中均可检测到TGF-β1样活性，但在MESO的7例中有5例以及少数原发性肺癌病例中检测到了TGF-β2样活性。这些结果表明，总TGF-β水平和TGF-β2样活性在临床上可能有助于鉴别MESO和原发性肺癌。我们的数据还提示，TGF-β可能有助于进一步明确MESO的临床特征。
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