Ai C X, Zhang W F, Zhao J H
Institute of Basic Medical Sciences, Beijing, China.
Microbiol Immunol. 1994;38(7):505-9. doi: 10.1111/j.1348-0421.1994.tb01815.x.
A sero-epidemiological investigation on Lyme disease was carried out in a forestry center of Hailin County, Heilongjiang Province, China. A total of 381 participants including forestry workers and their dependents completed questionnaires and had blood samples taken for detection of antibody against Borrelia burgdorferi by indirect immunofluorescent assay. Of 381 participants, 250 (65.6%) had a history of tick bites between May and July, 1987, and 379 (99.5%) at some time in the past, 56 (14.7%) developed erythema migrans at the site of tick attachment, 138 (36.2%) had late manifestations of Lyme disease, and 101 (26.2%) were seropositive. There was a significant difference in the seropositive rate between the persons with tick bites and those without tick bites in 1987 (P < 0.01). The titers in the older age group (over 30) were slightly higher than those of the younger age group (under 30). No relationship between the prevalence of Lyme manifestations by tick bites and the result of serological test was observed. Further investigations are necessary to assess the actual prevalence and incidence of infections using antigen of Lyme disease borreliae isolated in China.
在中国黑龙江省海林县的一个林业中心开展了一项莱姆病血清流行病学调查。共有381名参与者，包括林业工人及其家属，完成了问卷调查，并采集血样，通过间接免疫荧光法检测抗伯氏疏螺旋体抗体。在381名参与者中，250人（65.6%）有在1987年5月至7月期间被蜱叮咬的病史，379人（99.5%）在过去的某个时间有过被蜱叮咬的经历，56人（14.7%）在蜱叮咬部位出现游走性红斑，138人（36.2%）有莱姆病的晚期表现，101人（26.2%）血清学呈阳性。1987年有蜱叮咬史的人与无蜱叮咬史的人之间血清阳性率存在显著差异（P<0.01）。年龄较大组（30岁以上）的滴度略高于年龄较小组（30岁以下）。未观察到蜱叮咬导致的莱姆病表现患病率与血清学检测结果之间的关系。有必要进一步开展调查，以利用在中国分离的莱姆病疏螺旋体抗原评估感染的实际患病率和发病率。
