Keller J C, Stanford C M, Wightman J P, Draughn R A, Zaharias R
Dows Institute for Dental Research and the Center for Oral and Maxillofacial Implants, University of Iowa, Iowa City 52242.
J Biomed Mater Res. 1994 Aug;28(8):939-46. doi: 10.1002/jbm.820280813.
There are several reports in the literature concerning the similarities and the differences between the oxide on cpTi and Ti-6A1-4V alloy; however, their biological sequelae are not entirely known. In this work, a series of surface characterization techniques were used in conjunction with short term in vitro biological assays to assess the effects of materials selection (cpTi and Ti alloy) on osteoblast-like cell responses. Surface analysis indicated that with the exception of oxide thickness, there were no significant differences in surface characteristics between the two implant materials. These results were reflected in the biological studies, where the levels of cell attachment and adaptation of the attached cells to the titanium surfaces were similar. These results are in general agreement with previous in vivo studies and continue to indicate that cpTi and Ti alloy are suitable, biologically compatible materials for fabrication of dental implants.
文献中有几篇关于纯钛（cpTi）和Ti-6Al-4V合金表面氧化物异同的报道；然而，它们的生物学后遗症尚不完全清楚。在这项工作中，一系列表面表征技术与短期体外生物学试验相结合，以评估材料选择（纯钛和钛合金）对成骨样细胞反应的影响。表面分析表明，除了氧化物厚度外，两种植入材料的表面特性没有显著差异。这些结果在生物学研究中得到了体现，即细胞附着水平以及附着细胞对钛表面的适应性在两种材料上相似。这些结果与先前的体内研究总体一致，并继续表明纯钛和钛合金是适合制造牙科植入物的生物相容性材料。
