Pillar G, Peled R, Lavie P
Sleep Laboratory, Bruce Rapapport Faculty of Medicine, Technion--Israel Institute of Technology, Haifa.
Chest. 1994 Dec;106(6):1702-4. doi: 10.1378/chest.106.6.1702.
In this study we report on a long-term follow-up of 14 morbidly obese sleep apneic patients, 11 of whom were male and 3 female. The mean age was 46 +/- 8.5 years. These patients had undergone weight reduction surgery. Before surgery, body mass index (BMI) and apnea index (AI) were 45 +/- 7.2 kg/m2 and 40 +/- 28.8 (SD) h-1, respectively. Four and a half months after surgery (range, 2 to 7 months), both BMI and AI significantly decreased to 33 +/- 7.5 kg/m2 and 11 +/- 16.4 h-1, respectively. Seven and half years after surgery (range, 5 to 10 years), BMI increased only slightly to 35 +/- 6.0 kg/m2 (p > 0.2), while AI increased significantly to 24 +/- 23 h-1 (p < 0.05). There were poor and insignificant correlations between changes in BMI and AI prior to 4.5 months after operation (r = 0.23; p > 0.4). and 4.5 months to 7.5 years after operation (r = 0.41; p > 0.1). We conclude that morbid obesity is not the only causative factor in the sleep apnea syndrome for these patients. Weight reduction surgery alone does not "cure" their sleep apnea, and they are still at risk.
在本研究中，我们报告了14例病态肥胖的睡眠呼吸暂停患者的长期随访情况，其中男性11例，女性3例。平均年龄为46±8.5岁。这些患者均接受了减重手术。手术前，体重指数（BMI）和呼吸暂停指数（AI）分别为45±7.2kg/m²和40±28.8（标准差）次/小时。手术后4个半月（范围为2至7个月），BMI和AI均显著下降，分别降至33±7.5kg/m²和11±16.4次/小时。手术后七年半（范围为5至10年），BMI仅略有增加至35±6.0kg/m²（p>0.2），而AI显著增加至24±23次/小时（p<0.05）。在术后4.5个月之前，BMI和AI的变化之间相关性较差且无统计学意义（r=0.23；p>0.4），在术后4.5个月至7.5年之间，相关性也较差（r=0.41；p>0.1）。我们得出结论，病态肥胖并非这些患者睡眠呼吸暂停综合征的唯一致病因素。单纯的减重手术并不能“治愈”他们的睡眠呼吸暂停，他们仍然处于危险之中。
