Maes B D, Ghoos Y F, Rutgeerts P J, Hiele M I, Geypens B, Vantrappen G
Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium.
Dig Dis Sci. 1994 Dec;39(12 Suppl):104S-106S. doi: 10.1007/BF02300385.
We have developed a breath test to measure solid gastric emptying using a standardized scrambled egg test meal (250 kcal) labeled with [14C]octanoic acid or [13C]octanoic acid. In vitro incubation studies showed that octanoic acid is a reliable marker of the solid phase. The breath test was validated in 36 subjects by simultaneous radioscintigraphic and breath test measurements. Nine healthy volunteers were studied after intravenous administration of 200 mg erythromycin and peroral administration of 30 mg propantheline, respectively. Erythromycin significantly enhanced gastric emptying, while propantheline significantly reduced gastric emptying rates. We conclude that the [*C]octanoic breath test is a promising and reliable test for measuring the gastric emptying rate of solids.
我们开发了一种呼气试验，通过使用标记有[14C]辛酸或[13C]辛酸的标准化炒蛋试验餐（250千卡）来测量固体胃排空。体外孵育研究表明，辛酸是固相的可靠标志物。通过同时进行放射性核素闪烁显像和呼气试验测量，在36名受试者中对该呼气试验进行了验证。分别对9名健康志愿者静脉注射200毫克红霉素和口服30毫克丙胺太林后进行了研究。红霉素显著增强胃排空，而丙胺太林显著降低胃排空率。我们得出结论，[*C]辛酸呼气试验是一种用于测量固体胃排空率的有前景且可靠的试验。
