Perussia B, Tossi B, Rugarli C
Ric Clin Lab. 1976 Oct-Dec;6(4):326-31. doi: 10.1007/BF02899979.
A study of T and B cell surface markers was carried out on peripheral blood lymphocytes from diabetic patients, employing immunofluorescent staining for membrane Ig, and the E rosette test. According to the immunofluorescent studies the % of sIg bearing lymphocytes decreases with age; this trend is more evident in healthy individuals. Lymphocytes from diabetic patients posses a higher amount of membrane IgG than age-matched controls. It was only in the younger diabetic patients that a definite decrease was observed in the % of IgM bearing lymphocytes. The evaluation of E rosette-forming lymphocytes revealed a similar age-associated reduction both in diabetics and in controls. Some common features of the pattern of T and B cell markers on lymphocytes from younger diabetic patients and older controls suggest that the former undergo, at least from the immunological standpoint, a more precocious ageing process. It is possible that some metabolic disorders in lymphocyte activity may play a role in this, resulting in a deficiency in the control of immunological mechanisms.
对糖尿病患者外周血淋巴细胞进行了T细胞和B细胞表面标志物的研究，采用膜免疫球蛋白免疫荧光染色和E玫瑰花结试验。根据免疫荧光研究，带有表面免疫球蛋白（sIg）的淋巴细胞百分比随年龄增长而降低；这种趋势在健康个体中更为明显。糖尿病患者的淋巴细胞比年龄匹配的对照组拥有更多的膜免疫球蛋白G（IgG）。仅在较年轻的糖尿病患者中，观察到带有免疫球蛋白M（IgM）的淋巴细胞百分比有明确下降。对形成E玫瑰花结的淋巴细胞的评估显示，糖尿病患者和对照组中都有类似的与年龄相关的减少。较年轻糖尿病患者和老年对照组淋巴细胞上T细胞和B细胞标志物模式的一些共同特征表明，至少从免疫学角度来看，前者经历了更早熟的衰老过程。淋巴细胞活性中的某些代谢紊乱可能在此起作用，导致免疫机制控制不足。
