体外大肠杆菌转运RNA作为病毒逆转录的抑制剂
E. coli tRNAs as inhibitors of viral reverse transcription in vitro.
作者信息
Cavalieri L F, Yamaura I
出版信息
Nucleic Acids Res. 1975 Dec;2(12):2315-28. doi: 10.1093/nar/2.12.2315.
Abstract
Reverse transcription of 70S AMV RNA by AMV reverse transcriptase has been studied in the presence of E. coli tRNAs. We have shown that inhibition of DNA synthesis occurs and that the tRNAs bind to the enzyme and not to the 70S RNA. The results have implications for the control of reverse transcription in vivo.
摘要
在大肠杆菌转运RNA存在的情况下，对禽成髓细胞瘤病毒逆转录酶将70S禽成髓细胞瘤病毒RNA逆转录的过程进行了研究。我们已经表明，DNA合成受到抑制，并且转运RNA与该酶结合，而不是与70S RNA结合。这些结果对体内逆转录的控制具有启示意义。
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