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大鼠的一个新的保守基因,其在睾丸中受到发育调控。

A novel, conserved gene of the rat that is developmentally regulated in the testis.

作者信息

Walter L, Dirks B, Rothermel E, Heyens M, Szpirer C, Levan G, Günther E

机构信息

Division of Immunogenetics, University of Göttingen, Germany.

出版信息

Mamm Genome. 1994 Apr;5(4):216-21. doi: 10.1007/BF00360548.

Abstract

From a rat testis library three overlapping cDNA clones were isolated that represent a novel single-copy gene, designated Tegt. Two transcripts of 2.8 and 1.0 kb were found in each organ tested. The shorter transcript was highly abundant in adult testis. A similar expression pattern was found in the mouse. Analysis of rat RNA from different stages of spermatogenesis indicated that accumulation of the short transcript occurred mainly postmeiotically. The rat Tegt gene maps to Chromosome (Chr) 7, and its mouse homolog to Chr 15.

摘要

从大鼠睾丸文库中分离出三个重叠的cDNA克隆,它们代表一个新的单拷贝基因,命名为Tegt。在所检测的每个器官中都发现了2.8 kb和1.0 kb的两种转录本。较短的转录本在成年睾丸中高度丰富。在小鼠中也发现了类似的表达模式。对来自大鼠不同精子发生阶段的RNA分析表明,短转录本的积累主要发生在减数分裂后。大鼠Tegt基因定位于7号染色体(Chr),其小鼠同源基因定位于15号染色体。

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