Lampe J W, Martini M C, Kurzer M S, Adlercreutz H, Slavin J L
Department of Food Science and Nutrition, University of Minnesota, St Paul 55108.
Am J Clin Nutr. 1994 Jul;60(1):122-8. doi: 10.1093/ajcn/60.1.122.
Lignans and isoflavonoid phytoestrogens, produced from plant precursors by colonic bacteria, may protect against certain cancers. We examined the effects of flaxseed consumption on urinary lignans and isoflavonoids. Eighteen women consumed their usual omnivorous diets for three menstrual cycles and their usual diets supplemented with flaxseed powder (10 g/d) for three cycles in a randomized crossover design. Three-day urine samples from follicular and luteal phases were analyzed for lignans and isoflavonoids by isotope-dilution gas chromatography--mass spectrometry. Excretion of the lignans enterodiol and enterolactone increased with flaxseed from 1.09 +/- 1.08 and 3.16 +/- 1.47 to 19.48 +/- 1.10 and 27.79 +/- 1.50 mumol/d, respectively (P < 0.0002). Enterodiol and enterolactone excretion varied among subjects in response to flaxseed (3- to 285-fold increase). There were no differences in excretion of isoflavonoids (daidzein, genistein, equol, and O-desmethylangolensin) or the lignan matairesinol with flaxseed. Excretion was not altered by phase of menstrual cycle or duration of flaxseed consumption.
木脂素和异黄酮类植物雌激素由结肠细菌作用于植物前体产生，可能对某些癌症具有预防作用。我们研究了食用亚麻籽对尿中木脂素和异黄酮的影响。18名女性采用随机交叉设计，在三个月经周期中食用其通常的杂食性饮食，并在另外三个周期中食用添加了亚麻籽粉（10克/天）的常规饮食。通过同位素稀释气相色谱-质谱法分析卵泡期和黄体期的三天尿液样本中的木脂素和异黄酮。食用亚麻籽后，木脂素肠二醇和肠内酯的排泄量分别从1.09±1.08和3.16±1.47增加到19.48±1.10和27.79±1.50微摩尔/天（P<0.0002）。肠二醇和肠内酯的排泄量在不同受试者中对亚麻籽的反应有所不同（增加3至285倍）。食用亚麻籽后，异黄酮（大豆苷元、染料木黄酮、雌马酚和O-去甲基安哥拉紫檀素）或木脂素罗汉松脂醇的排泄量没有差异。排泄量不受月经周期阶段或食用亚麻籽持续时间的影响。
