Peltonen R, Kjeldsen-Kragh J, Haugen M, Tuominen J, Toivanen P, Førre O, Eerola E
Department of Medical Microbiology, University of Turku, Finland.
Br J Rheumatol. 1994 Jul;33(7):638-43. doi: 10.1093/rheumatology/33.7.638.
The beneficial effect of a 1-yr vegetarian diet in RA has recently been demonstrated in a clinical trial. We have analysed stool samples of the 53 RA patients by using direct stool sample gas-liquid chromatography of bacterial cellular fatty acids. Based on repeated clinical assessments disease improvement indices were constructed for the patients. At each time point during the intervention period the patients in the diet group were then assigned either to a group with a high improvement index (HI) or a group with a low improvement index (LI). Significant alteration in the intestinal flora was observed when the patients changed from omnivorous to vegan diet. There was also a significant difference between the periods with vegan and lactovegetarian diets. The faecal flora from patients with HI and LI differed significantly from each other at 1 and 13 months during the diet. This finding of an association between intestinal flora and disease activity may have implications for our understanding of how diet can affect RA.
近期一项临床试验证明了为期1年的素食饮食对类风湿性关节炎（RA）的有益效果。我们通过对53例RA患者的粪便样本进行细菌细胞脂肪酸直接粪便样本气液色谱分析。基于反复的临床评估，为患者构建了疾病改善指标。在干预期的每个时间点，饮食组的患者随后被分为高改善指标（HI）组或低改善指标（LI）组。当患者从杂食饮食转变为纯素饮食时，观察到肠道菌群有显著变化。纯素饮食期和乳素饮食期之间也存在显著差异。在饮食期间的第1个月和第13个月，HI组和LI组患者的粪便菌群彼此有显著差异。肠道菌群与疾病活动之间存在关联这一发现可能对我们理解饮食如何影响RA有重要意义。
