用伯氏疏螺旋体外表面蛋白诱导实验性变应性关节炎
Induction of experimental allergic arthritis with outer surface proteins of Borrelia burgdorferi.
作者信息
Gondolf K B, Mihatsch M, Curschellas E, Dunn J J, Batsford S R
机构信息
Institute for Medical Microbiology, Freiburg, Germany.
出版信息
Arthritis Rheum. 1994 Jul;37(7):1070-7. doi: 10.1002/art.1780370713.
OBJECTIVE
The arthritogenic potential of the cationic outer surface proteins (Osp) from Borrelia burgdorferi was tested in rats.
METHODS
Water-soluble Osps were prepared by butanol extraction and were administered by intraarticular injection. Tissue injury was assessed by scintigraphy and histology.
RESULTS
A mild arthritis was seen in naive rats. Preimmunized animals had more severe, longer lasting bouts of inflammation.
CONCLUSION
The Osps of Borrelia burgdorferi are potent arthritogens in rats. These immunodominant antigens may play a role in the development of Lyme arthritis in humans.
目的
在大鼠中测试来自伯氏疏螺旋体的阳离子外表面蛋白（Osp）的致关节炎潜力。
方法
通过丁醇萃取制备水溶性Osp，并通过关节内注射给药。通过闪烁扫描术和组织学评估组织损伤。
结果
在未免疫的大鼠中观察到轻度关节炎。预先免疫的动物有更严重、持续时间更长的炎症发作。
结论
伯氏疏螺旋体的Osp在大鼠中是强效致关节炎因子。这些免疫显性抗原可能在人类莱姆关节炎的发展中起作用。
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