来自红藻 Nothogenia fastigiata 的一种硫酸化多糖的抗病毒活性。

Antiviral activity of a sulphated polysaccharide from the red seaweed Nothogenia fastigiata.

作者信息

Damonte E, Neyts J, Pujol C A, Snoeck R, Andrei G, Ikeda S, Witvrouw M, Reymen D, Haines H, Matulewicz M C

机构信息

Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.

出版信息

Biochem Pharmacol. 1994 Jun 15;47(12):2187-92. doi: 10.1016/0006-2952(94)90254-2.

DOI:10.1016/0006-2952(94)90254-2

PMID:8031312

Abstract

The antiviral activity of polysaccharide fractions obtained from water extracts of the red seaweed Nothogenia fastigiata was investigated. Fraction F6, corresponding to a sulphated xylomannan, was found to inhibit efficiently the replication of herpes simplex virus type 1 (HSV-1). Furthermore, F6 selectively inhibited the replication of several other enveloped viruses including herpes simplex virus type 2, human cytomegalovirus (HCMV), respiratory syncytial virus, influenza A and B virus, Junin and Tacaribe virus and simian immunodeficiency virus. F6 was only weakly active against human immunodeficiency virus type 1 and 2. The mode of action of F6 against HSV-1 and HCMV could be ascribed to an inhibitory effect on virus adsorption.

摘要

对从红藻Nothogenia fastigiata水提取物中获得的多糖级分的抗病毒活性进行了研究。对应于硫酸化木聚糖甘露聚糖的级分F6被发现能有效抑制1型单纯疱疹病毒（HSV-1）的复制。此外，F6选择性地抑制了其他几种包膜病毒的复制，包括2型单纯疱疹病毒、人巨细胞病毒（HCMV）、呼吸道合胞病毒、甲型和乙型流感病毒、胡宁病毒和塔卡里贝病毒以及猴免疫缺陷病毒。F6对1型和2型人类免疫缺陷病毒的活性较弱。F6对HSV-1和HCMV的作用方式可归因于对病毒吸附的抑制作用。