Bernasconi S, Larizza D, Benso L, Volta C, Vannelli S, Milani S, Aicardi G, Berardi R, Borrelli P, Boscherini B
Istituto di Clinica Pediatrica, Università di Parma, Italy.
Acta Paediatr. 1994 Mar;83(3):292-8. doi: 10.1111/j.1651-2227.1994.tb18097.x.
In 1990, the Italian Study Group for Turner's Syndrome (ISGTS) undertook a nationwide survey, involving the retrospective collection of cross-sectional data and longitudinal growth profiles of 772 girls with Turner's syndrome born between 1950 and 1990. The study was carried out in 29 pediatric endocrinological centers. In this first report, the familial characteristics and neonatal data of Turner girls are described, compared to those of the general population, and related to postnatal somatic development. Furthermore, charts for birth weight and growth standards for height and weight from infancy to adulthood are presented (these are the first charts based on a large sample from the Mediterranean area). The main findings were: (1) incidence of Turner births increases with parental age or parity; (2) most of the neonates are small for dates; (3) girls with normal birth weight tend to be both taller and heavier than girls with low birth weight during the whole growth period; and (4) a 10-cm difference in midparental height leads to a 6.5-cm difference in adult stature.
1990年，意大利特纳综合征研究小组（ISGTS）开展了一项全国性调查，回顾性收集了1950年至1990年间出生的772名特纳综合征女孩的横断面数据和纵向生长曲线。该研究在29个儿科内分泌中心进行。在这份首份报告中，描述了特纳综合征女孩的家族特征和新生儿数据，并与普通人群的相关数据进行比较，还将其与出生后身体发育情况相关联。此外，还给出了从婴儿期到成年期的出生体重图表以及身高和体重生长标准（这些是基于地中海地区大量样本得出的首批图表）。主要研究结果如下：（1）特纳综合征患儿的出生率随父母年龄或生育次数增加而上升；（2）大多数新生儿小于胎龄；（3）在整个生长期间，出生体重正常的女孩往往比出生体重低的女孩更高、更重；（4）父母平均身高相差10厘米，成年身高相差6.5厘米。
