al-Khaldi N, Watson A R, Zuccollo J, Twining P, Rose D H
Department of Paediatric Nephrology, City Hospital, Nottingham.
Arch Dis Child. 1994 Jun;70(6):520-2. doi: 10.1136/adc.70.6.520.
Forty four fetuses with multicystic dysplastic kidney (MCDK) disease recognised on antenatal ultrasound were studied prospectively. In nine aborted fetuses and in five who died in the neonatal period the MCDK disease was bilateral or there were associated lethal abnormalities or syndromes. All surviving infants had unilateral disease and in six (20%) there was significant reflux into the normal contralateral kidney. Since 1988 the management of unilateral MCDK disease has been conservative with no child developing sepsis, hypertension, or malignancy. Serial ultrasound examinations suggest that MCDK lesions involute with time and conservative rather than operative management is favoured.
对44例产前超声诊断为多囊性发育不良肾（MCDK）疾病的胎儿进行了前瞻性研究。在9例流产胎儿和5例新生儿期死亡的胎儿中，MCDK疾病为双侧性，或伴有致命性异常或综合征。所有存活婴儿均为单侧疾病，其中6例（20%）对侧正常肾脏有明显反流。自1988年以来，单侧MCDK疾病的治疗一直采取保守治疗，没有患儿发生败血症、高血压或恶性肿瘤。系列超声检查表明，MCDK病变会随时间逐渐消退，因此更倾向于保守治疗而非手术治疗。
