梅毒螺旋体对小鼠无感染性的新证据。
New evidence for the non-infectivity of Treponema pallidum for mice.
作者信息
Schell R F, Musher D M, Jacobson K, Schwethelm P
出版信息
Br J Vener Dis. 1975 Feb;51(1):19-21. doi: 10.1136/sti.51.1.19.
Abstract
We have recently shown that syphilitic rabbits are resistant to challenge with Listeria monocytogenes. This resistance was thought to reflect stimulation of cell-mediated immunity by active infection with Treponema pallidum. We now report data which show that the growth of Listeria was not suppressed in mice inoculated with T. pallidum. Re-inoculation with T, pallidum or with a large dose of an avirulent treponeme also failed to suppress the growth of Listeria. These results contrast with those obtained in rabbits and provide additional evidence that T. pallidum is not infective for the mouse.
摘要
我们最近发现，感染梅毒的兔子对单核细胞增生李斯特菌的攻击具有抵抗力。这种抵抗力被认为反映了梅毒螺旋体的活跃感染对细胞介导免疫的刺激作用。我们现在报告的数据表明，接种梅毒螺旋体的小鼠体内，李斯特菌的生长并未受到抑制。再次接种梅毒螺旋体或大剂量无毒力的密螺旋体也未能抑制李斯特菌的生长。这些结果与在兔子身上获得的结果形成对比，并提供了额外的证据，证明梅毒螺旋体对小鼠无感染性。
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