Goldstein F C, Levin H S, Presley R M, Searcy J, Colohan A R, Eisenberg H M, Jann B, Bertolino-Kusnerik L
Emory University School of Medicine, Atlanta, Georgia.
J Neurol Neurosurg Psychiatry. 1994 Aug;57(8):961-6. doi: 10.1136/jnnp.57.8.961.
This study examined the neurobehavioural effects of closed head injury (CHI) in adults aged 50 years and older. Twenty two mild to moderate CHI patients who were within seven months of the injury were administered measures of language, memory, attention, and executive functioning. Compared with demographically similar normal controls, the patients exhibited significantly poorer functioning on the cognitive domains. Naming and word fluency under timed conditions, verbal and visual memory, and the ability to infer similarities were especially vulnerable. These initial findings indicate that CHI in older adults produces considerable cognitive deficits in the early stages of recovery. Future research should characterise long term outcome and the potential links between head injury and the development of progressive dementia.
本研究调查了50岁及以上成年人闭合性颅脑损伤（CHI）的神经行为影响。22名损伤发生在7个月内的轻至中度CHI患者接受了语言、记忆、注意力和执行功能的测试。与人口统计学特征相似的正常对照组相比，这些患者在认知领域的功能明显较差。限时条件下的命名和词汇流畅性、言语和视觉记忆以及推断相似性的能力尤其容易受到影响。这些初步研究结果表明，老年人的闭合性颅脑损伤在恢复早期会产生相当大的认知缺陷。未来的研究应明确长期结果以及头部损伤与进行性痴呆发展之间的潜在联系。
