奥美拉唑治疗前、治疗期间及治疗后的胃内细菌活性及亚硝化作用。
Intragastric bacterial activity and nitrosation before, during, and after treatment with omeprazole.
作者信息
Sharma B K, Santana I A, Wood E C, Walt R P, Pereira M, Noone P, Smith P L, Walters C L, Pounder R E
出版信息
Br Med J (Clin Res Ed). 1984 Sep 22;289(6447):717-9. doi: 10.1136/bmj.289.6447.717.
Abstract
Ten healthy volunteers were studied before, during, and after treatment with omeprazole 30 mg daily for two weeks. On the 14th night mean nocturnal (2100-0700) intragastric acidity was significantly decreased by 75% (p less than 0.001). At 0700, 22 hours after the last dose of omeprazole, there were significant increases in the bacterial count and the nitrite and N-nitrosamine concentrations in the gastric juice (p less than 0.001). Three days later these changes had resolved. Short term treatment of healthy volunteers with omeprazole is associated with a short lived increase in the gastric bacterial flora, with endogenous production of N-nitroso compounds.
摘要
对10名健康志愿者在每日服用30毫克奥美拉唑治疗两周的前、治疗期间及治疗后进行了研究。在第14个夜晚，夜间（21:00至07:00）胃内酸度平均显著降低了75%（p<0.001）。在最后一剂奥美拉唑服用22小时后的07:00，胃液中的细菌计数、亚硝酸盐和N-亚硝胺浓度显著增加（p<0.001）。三天后这些变化消失。健康志愿者短期服用奥美拉唑与胃内细菌菌群短暂增加及内源性N-亚硝基化合物生成有关。
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