Fallingborg J, Christensen L A, Jacobsen B A, Ingeman-Nielsen M, Rasmussen H H, Abildgaard K, Rasmussen S N
Dept. of Medical Gastroenterology, Aalborg Hospital, Denmark.
Scand J Gastroenterol. 1994 Jun;29(6):498-500. doi: 10.3109/00365529409092461.
Treatment of inflammatory bowel disease with olsalazine causes diarrhoea in 10% of patients. This is claimed to be caused by a drug effect on mucosal transport in the small intestine, which might be reflected in the intraluminal pH. We aimed to study the effect on jejunal pH of olsalazine (Dipentum) and an alternative preparation, slow-release mesalazine (Pentasa).
Thirteen healthy volunteers, seven male and six female, participated in a randomized, crossover study. Steady-state conditions were obtained after ingestion of 2 g or 6 g mesalazine daily or 2 g olsalazine daily for 1 week. The pH of the duodenum and proximal jejunum was measured by using pH-sensitive, radiotransmitting capsules, the location of which was confirmed by fluoroscopy.
No effect of either drug on duodenal pH was detected. Mean duodenal pH ranged from 6.18 to 6.22. The mean pH of the pre-medication proximal jejunum was 6.02. Mesalazine had no significant effect, but olsalazine significantly increased the pH of the proximal jejunum (mean pH, 6.47).
Our results indicate that the effect of olsalazine on jejunal transport of electrolytes and water, observed in experimental studies, also applies to human subjects in steady-state conditions, and adaptation does not occur within 6 days.
用奥沙拉嗪治疗炎性肠病会导致10%的患者出现腹泻。据称这是由药物对小肠黏膜转运的作用引起的，这可能反映在肠腔内pH值上。我们旨在研究奥沙拉嗪（安萨科）和另一种制剂缓释美沙拉嗪（颇得斯安）对空肠pH值的影响。
13名健康志愿者，7名男性和6名女性，参与了一项随机交叉研究。在每天摄入2克或6克美沙拉嗪或2克奥沙拉嗪，持续1周后达到稳态条件。使用对pH敏感的放射性传输胶囊测量十二指肠和空肠近端的pH值，其位置通过荧光透视确认。
未检测到两种药物对十二指肠pH值有影响。十二指肠平均pH值在6.18至6.22之间。用药前空肠近端的平均pH值为6.02。美沙拉嗪无显著影响，但奥沙拉嗪显著提高了空肠近端的pH值（平均pH值为6.47）。
我们的结果表明，在实验研究中观察到的奥沙拉嗪对空肠电解质和水转运的影响，在稳态条件下也适用于人类受试者，并且在6天内不会发生适应性变化。
