淋病奈瑟菌对青霉素敏感性降低的可能机制。
Possible mechanism of decreased susceptibility of Neisseria gonorrhoeae to penicillin.
作者信息
Rodriguez W, Saz A K
出版信息
Antimicrob Agents Chemother. 1975 Jun;7(6):788-92. doi: 10.1128/AAC.7.6.788.
Abstract
By use of (14)C-labeled benzyl penicillin, it has been established that beta-lactamases and/or acylases play no role in the resistance of Neisseria gonorrhoeae to penicillin. It has been found, however, that very susceptible strains of the organisms (minimal inhibitory concentration, 0.008 mug/ml) bind 10 to 15 times as much penicillin as do moderately to highly resistant strains of the gonoccoccus (minimal inhibitory concentration, 0.125 to 2.0 mug/ml). It is postulated that this degree of change in binding components of the whole cell and whole cytoplasmic membrane is sufficient to account for the decreased susceptibility of the organism to penicillin.
摘要
通过使用碳-14标记的苄青霉素，已证实β-内酰胺酶和/或酰基酶在淋病奈瑟菌对青霉素的耐药性中不起作用。然而，已发现该微生物的非常敏感菌株（最低抑菌浓度为0.008微克/毫升）结合的青霉素量是淋病双球菌中度至高度耐药菌株（最低抑菌浓度为0.125至2.0微克/毫升）的10至15倍。据推测，全细胞和全细胞膜结合成分的这种变化程度足以解释该微生物对青霉素敏感性的降低。
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