Malik V B, Ahluwalia P
Department of Biochemistry, Punjab University, Chandigarh, India.
Toxicol Lett. 1994 Oct;74(1):69-77. doi: 10.1016/0378-4274(94)90075-2.
Monosodium glutamate (MSG) was administered subcutaneously to adult male mice for 6 days at dose levels of 2, 4, and 8 mg/g body wt. Dose levels above 4 mg/g body wt. showed significant increase in content of liver total lipids, phospholipids, triglycerides and free fatty acids, 31 days after the last injection. Blood glutamate level was significantly increased in all the groups but blood glutamine was increased in 4 and 8 mg/g body wt. groups (Groups III and IV) only. Blood pyruvate and glucose was significantly increased whereas liver glycogen and blood lactate was decreased in group III and IV. Activity of lactate dehydrogenase was significantly reduced both in serum and liver but the activity of glucose-6-phosphate dehydrogenase was significantly increased in RBC and liver at dose levels of 4 and 8 mg/g body wt. All these observations are suggestive of the fact that carbohydrate metabolism is shifted towards lipogenesis and hence leads to hyperlipidemia.
将味精（MSG）以2、4和8毫克/克体重的剂量水平皮下注射给成年雄性小鼠，持续6天。在最后一次注射31天后，体重剂量高于4毫克/克体重时，肝脏总脂质、磷脂、甘油三酯和游离脂肪酸的含量显著增加。所有组的血液谷氨酸水平均显著升高，但只有体重剂量为4和8毫克/克体重的组（第三组和第四组）血液谷氨酰胺升高。第三组和第四组的血液丙酮酸和葡萄糖显著升高，而肝糖原和血液乳酸降低。在体重剂量为4和8毫克/克体重时，血清和肝脏中的乳酸脱氢酶活性显著降低，但红细胞和肝脏中的葡萄糖-6-磷酸脱氢酶活性显著升高。所有这些观察结果表明，碳水化合物代谢向脂肪生成方向转变，从而导致高脂血症。
