Piepsz A, Pintelon H, Ham H R
Department of Radioisotopes, Academic Hospital, VUB, Brussels, Belgium.
Eur J Nucl Med. 1994 Jan;21(1):12-6. doi: 10.1007/BF00182300.
In order to estimate the normal range of chromium-51 ethylene diamine tetra-acetic acid (EDTA) clearance in children, we selected a series of 256 patients with past or present urinary tract infection who showed, at the time of the clearance determination, normal technetium-99m dimercaptosuccinic acid (DMSA) scintigraphy and normal left to right DMSA relative uptake. The clearance was calculated by means of either the simplified second exponential method or the 120-min single blood sample; Chantler's correction was used in order to correct for having neglected the first exponential. There was a progressive increase in clearance from the first weeks of life (mean value around 1 month: 55 ml/min/1.73 m2), with a plateau at around 18 months. Between 2 and 17 years of age, the clearance values remained constant, with a mean value of 114 ml/min/1.73 m2 (SD: 24 ml/min); this is similar to the level described for inulin clearance. No significant differences were observed between boys and girls, or between clearance values calculated with one or with two blood samples. Taking into account the hour of intravenous injection of the tracer, we did not observe any influence of the lunchtime meal on the distribution of the 51Cr-EDTA clearance values.
为了估算儿童51铬-乙二胺四乙酸（EDTA）清除率的正常范围，我们选取了256例有既往或当前尿路感染病史的患者，这些患者在进行清除率测定时，99m锝二巯基丁二酸（DMSA）闪烁扫描正常，且左右DMSA相对摄取正常。清除率通过简化的二次指数法或120分钟单血样法计算；使用钱特勒校正法来校正忽略的第一次指数。从生命的最初几周开始，清除率逐渐增加（1个月左右的平均值：55毫升/分钟/1.73平方米），在18个月左右达到平稳状态。在2至17岁之间，清除率值保持恒定，平均值为114毫升/分钟/1.73平方米（标准差：24毫升/分钟）；这与菊粉清除率所描述的水平相似。在男孩和女孩之间，以及用单血样或双血样计算的清除率值之间，均未观察到显著差异。考虑到示踪剂静脉注射的时间，我们未观察到午餐对51Cr-EDTA清除率值分布有任何影响。
