Kynast B, Binder L, Marx D, Zoll B, Schmoll H J, Oellerich M, Schauer A
Abt. Hämatologie Onkologie, Medizinische Hochschule Hannover, Federal Republic of Germany.
J Cancer Res Clin Oncol. 1993;119(5):249-52. doi: 10.1007/BF01212719.
Concentrations of a fragment of the c-erbB-2 translational product (p185 fragment) were measured in serum of 70 breast cancer patients, 19 healthy blood donors, and 18 pregnant women using a heterogenic enzyme immunoassay. The serum concentrations of blood donors and pregnant women were below 30 kU/l. Breast cancer patients showed serum concentrations up to 578 kU/l. All 9/70 patients with serum concentrations higher than 30 kU/l had clinical evidence of metastatic disease and the serum levels of all 35/70 patients without metastasis lay within the normal range. From 9/37 patients with p185 overexpression of the primary tumor in immunohistochemical analysis 3/9 patients with metastatic disease had elevated serum levels higher than 30 kU/l. In all, 6/9 patients without metastasis serum levels were below 30 kU/l. The data of the present study suggest that determination of serum p185 fragment concentrations may be useful as a diagnostic tool in postoperative follow-up of breast cancer patients with c-erbB-2 overexpression of the primary tumor.
采用异源性酶免疫分析法，对70例乳腺癌患者、19例健康献血者和18例孕妇的血清中c-erbB-2翻译产物片段（p185片段）的浓度进行了测定。献血者和孕妇的血清浓度低于30 kU/l。乳腺癌患者的血清浓度高达578 kU/l。所有9/70血清浓度高于30 kU/l的患者均有转移性疾病的临床证据，而所有35/70无转移患者的血清水平均在正常范围内。在免疫组织化学分析中，37例原发肿瘤p185过表达的患者中，9例有转移性疾病的患者中有3例血清水平升高超过30 kU/l。总体而言，9例无转移患者中有6例血清水平低于30 kU/l。本研究数据表明，测定血清p185片段浓度可能作为对原发肿瘤c-erbB-2过表达的乳腺癌患者术后随访的诊断工具。
