要素饮食诱导的细菌移位可通过激素调节。
Elemental diet-induced bacterial translocation can be hormonally modulated.
作者信息
Haskel Y, Xu D, Lu Q, Deitch E
机构信息
Department of Surgery, Louisiana State University Medical Center, Shreveport 71130-3932.
出版信息
Ann Surg. 1993 Jun;217(6):634-42; discussion 642-3. doi: 10.1097/00000658-199306000-00005.
BACKGROUND
The authors have previously documented that feeding mice an elemental diet resulted in bacterial translocation (BT) that could be prevented by the provision of dietary fiber. To test whether the protective effect of fiber was related to the stimulation of trophic gut hormones, the effects of sandostatin and bombesin were tested.
METHODS
Mice fed either chow or the elemental diet were stratified into several groups and the ability of bombesin (10 micrograms/kg, tid) or sandostatin (100 micrograms/kg bid) to modulate BT was examined. After 14 days, mice were sacrificed and BT, cecal bacterial population levels, mucosal protein, and small bowel weight was measured. Segments of the ileum and jejunum were examined histologically.
RESULTS
Incidence of elemental diet-induced BT (75%) was reduced by fiber (9%) or the administration of bombesin (13%) (p < 0.01). Although sandostatin did not promote BT in chow-fed mice, it reversed the protective effect of fiber on BT (75%) (p < 0.01).
CONCLUSION
Elemental diet-induced bacterial translocation can be modulated hormonally and the beneficial effects of fiber on diet-induced BT appears to be hormonally mediated.
背景
作者之前已证明，给小鼠喂食要素饮食会导致细菌移位（BT），而提供膳食纤维可预防这种情况。为了测试纤维的保护作用是否与对肠道营养激素的刺激有关，研究了生长抑素和蛙皮素的作用。
方法
将喂食普通饲料或要素饮食的小鼠分成几组，检测蛙皮素（10微克/千克，每日三次）或生长抑素（100微克/千克，每日两次）调节细菌移位的能力。14天后，处死小鼠并测量细菌移位、盲肠细菌数量水平、黏膜蛋白和小肠重量。对回肠和空肠段进行组织学检查。
结果
要素饮食诱导的细菌移位发生率（75%）因纤维（降至9%）或蛙皮素的给药（降至13%）而降低（p<0.01）。虽然生长抑素在喂食普通饲料的小鼠中未促进细菌移位，但它逆转了纤维对细菌移位的保护作用（升至75%）（p<0.01）。
结论
要素饮食诱导的细菌移位可通过激素调节，纤维对饮食诱导的细菌移位的有益作用似乎是由激素介导的。
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