梅森- Pfizer猴病毒：病毒粒子蛋白和糖蛋白的分析与定位
Mason-Pfizer monkey virus: analysis and localization of virion proteins and glycoproteins.
作者信息
Schochetman G, Kortright K, Schlom J
出版信息
J Virol. 1975 Nov;16(5):1208-19. doi: 10.1128/JVI.16.5.1208-1219.1975.
Abstract
The polypeptide composition of Mason-Pfizer monkey virus was determined using sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Six major polypeptides of molecular weights 68,000, 27,000, 20,000, 14,000, 12,000, and 10,000 were resolved regardless of the cell type (i.e., two human and two rhesus) in which the virus was grown. Protein gp68 (68,000) represented the major virus glycoprotein and protein gp20 (20,000) represented a minor glycoprotein of the virion, again regardless of the cell type of origin of the virus. Protein gp68 appears to be located on the outer surface of the viral envelope, as demonstrated by lactoperoxidase catalyzed iodination of intact virions. Additional glycoproteins were shown to be virion associated; their presence depended, however, on the cell type in which the virus was propagated.
摘要
利用十二烷基硫酸钠-聚丙烯酰胺凝胶电泳法测定了梅森- Pfizer猴病毒的多肽组成。无论病毒在何种细胞类型（即两种人类细胞和两种恒河猴细胞）中生长，均可分辨出分子量分别为68,000、27,000、20,000、14,000、12,000和10,000的六种主要多肽。蛋白gp68（68,000）代表主要的病毒糖蛋白，蛋白gp20（20,000）代表病毒粒子的一种次要糖蛋白，同样与病毒起源的细胞类型无关。如通过乳过氧化物酶催化完整病毒粒子的碘化反应所证明的，蛋白gp68似乎位于病毒包膜的外表面。还显示有其他糖蛋白与病毒粒子相关；然而，它们的存在取决于病毒所繁殖的细胞类型。
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