Shinohara T, Matsuda M, Cheng S H, Marshall J, Fujita M, Nagashima K
Department of Pathology, Hokkaido University School of Medicine, Sapporo, Japan.
J Med Virol. 1993 Dec;41(4):301-5. doi: 10.1002/jmv.1890410408.
By screening consecutive autopsy cases with an antibody that recognizes human polyomaviruses, we found a case of malignant lymphoma in which the virus infection was confined to epithelia of the renal calyces, renal pelvis, ureter, and urinary bladder. The virus was confirmed as BK virus by a specific monoclonal antibody against BK virus T antigen, and numerous virus particles were identified by electron microscopy. The results showed that BK virus is a human urotheliotrophic virus.
通过使用一种可识别人类多瘤病毒的抗体对连续的尸检病例进行筛查，我们发现了一例恶性淋巴瘤病例，其中病毒感染局限于肾盏、肾盂、输尿管和膀胱的上皮细胞。通过针对BK病毒T抗原的特异性单克隆抗体确认该病毒为BK病毒，并通过电子显微镜鉴定出大量病毒颗粒。结果表明BK病毒是一种人类尿路上皮嗜性病毒。
