Kay L, Jørgensen T
Medical Dept. C, KAS Glostrup, University of Copenhagen, Denmark.
Scand J Gastroenterol. 1994 Jan;29(1):2-6.
The prevalence, incidence, natural history, and risk factors of upper dyspepsia (UD) were evaluated in a random sample of Danes. Of the 4581 eligible subjects, 79% responded. Five years later 85% of the survivors attended a similar follow-up study. Depending on the frequency of the symptoms, the prevalence of UD was 13-54% among men and 15-47% among women, and the incidence was 5-22% and 6-25%, respectively. Five years later 26-69% of subjects with UD were free from symptoms. As an independent factor psychic vulnerability was most strongly related to prevalence and incidence of UD, whereas experience of problems, smoking, and body mass index were only weakly associated with prevalence of UD. A comparison of the populations identified by various definitions of UD showed that these populations had rather few subjects in common. In conclusion, UD occurs frequently and fluctuates in the general population. Only psychic vulnerability was strongly related to UD incidence. The syndrome, however, still needs to be verified as a disease entity.
在丹麦人的随机样本中评估了上消化道消化不良（UD）的患病率、发病率、自然史和危险因素。在4581名符合条件的受试者中，79%做出了回应。五年后，85%的幸存者参加了类似的随访研究。根据症状出现的频率，UD在男性中的患病率为13% - 54%，在女性中为15% - 47%，发病率分别为5% - 22%和6% - 25%。五年后，26% - 69%的UD患者症状消失。作为一个独立因素，心理易损性与UD的患病率和发病率关联最为密切，而问题经历、吸烟和体重指数与UD患病率仅存在微弱关联。对通过UD的各种定义所确定的人群进行比较发现，这些人群的共同受试者相当少。总之，UD在普通人群中频繁发生且有波动。只有心理易损性与UD发病率密切相关。然而，该综合征仍需作为一种疾病实体加以验证。
