克拉霉素与表皮葡萄球菌形成的生物膜之间的相互作用。
Interaction between clarithromycin and biofilms formed by Staphylococcus epidermidis.
作者信息
Yasuda H, Ajiki Y, Koga T, Yokota T
机构信息
Biological Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
出版信息
Antimicrob Agents Chemother. 1994 Jan;38(1):138-41. doi: 10.1128/AAC.38.1.138.
Abstract
Interactions between clarithromycin and biofilms formed by Staphylococcus epidermidis were investigated by using a clarithromycin-resistant strain. Treatment of the colonization with a relatively low concentration of clarithromycin resulted in the eradication of slime-like structure and a decrease in the quantity of hexose. Another result was increased penetration of antibiotics through the biofilm of S. epidermidis.
摘要
利用一株对克拉霉素耐药的菌株，研究了克拉霉素与表皮葡萄球菌形成的生物膜之间的相互作用。用相对低浓度的克拉霉素处理定植情况，导致黏液样结构消失以及己糖数量减少。另一个结果是抗生素穿透表皮葡萄球菌生物膜的能力增强。
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