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噬菌体SPP1的基因表达。II. 调控方面。

Gene expression of bacteriophage SPP1. II. Regulatory aspects.

作者信息

Esche H

出版信息

Mol Gen Genet. 1975 Dec 23;142(1):57-66. doi: 10.1007/BF00268755.

DOI:10.1007/BF00268755
PMID:814402
Abstract

The expression of late SPP1 genes depends on preceding SPP1 DNA replication. This is shown in nonpermissive infection with a mutant defective in DNA replication and after inhibition of DNA synthesis by HPUra. The potential for host gene expression is not significantly influenced by SPP1 infection, as evidenced by the continuation of host protein synthesis and the inducibility of glycerolphosphate dehydrogenase after infection. The involvement of a positive control element in the regulation of SPP1 gene expression is deduced from the observation that chloramphenicol prevents the synthesis of the only class of mRNA which is transcribed from the L-strand.

摘要

晚期SPP1基因的表达依赖于先前的SPP1 DNA复制。这在DNA复制缺陷的突变体的非允许感染中以及在HPUra抑制DNA合成后得到了证明。宿主基因表达的潜力不受SPP1感染的显著影响，感染后宿主蛋白合成的持续以及甘油磷酸脱氢酶的可诱导性证明了这一点。从氯霉素阻止从L链转录的唯一一类mRNA的合成这一观察结果推断，存在一个正调控元件参与SPP1基因表达的调控。

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本文引用的文献

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A method for the detection of RNA-DNA complexes.一种检测RNA-DNA复合物的方法。
Biochem Biophys Res Commun. 1963 Jul 18;12:98-104. doi: 10.1016/0006-291x(63)90242-0.
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Gene expression of bacteriophage SPPI. I. Phage directed protein synthesis.噬菌体SPPI的基因表达。I. 噬菌体指导的蛋白质合成。
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Bacillus subtilis DNA polymerase III is required for the replication of DNA of bacteriophages SPP-1 and phi 105.枯草芽孢杆菌DNA聚合酶III是噬菌体SPP - 1和phi 105的DNA复制所必需的。
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Mol Gen Genet. 1978 Nov 9;166(3):277-85.
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Restriction fragment analysis of bacteriophage SPP1 in vitro transcription by host RNA polymerase.宿主RNA聚合酶对噬菌体SPP1体外转录的限制片段分析。
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Bacteriophage SPP1 polypeptides synthesized in infected minicells and in vitro.在受感染的微小细胞中和体外合成的噬菌体SPP1多肽。
Mol Gen Genet. 1979;172(3):271-9. doi: 10.1007/BF00271726.
J Mol Biol. 1971 Jul 28;59(2):329-49. doi: 10.1016/0022-2836(71)90054-4.
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Control of DNA synthesis in Bacillus subtilis by phage phi e.噬菌体φe对枯草芽孢杆菌DNA合成的控制
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