Ghosh P K, York J P
Department of Surgery, Ohio State University, Columbus 43210.
J Surg Res. 1994 Mar;56(3):271-6. doi: 10.1006/jsre.1994.1043.
The present study was undertaken to determine the effects of surgically induced varicocele on testicular androgen production, seminiferous tubular diameter, and acid and alkaline phosphatase activities in testis and accessory sex organs in adult Noble rats. Testosterone concentrations in plasma and in both left and right testis were estimated in both sham-operated and varicocele-induced rats. The activities of acid and alkaline phosphatase were measured in both left and right testis, seminal vesicle, and ventral prostate gland in varicocele-induced and sham-operated rats. The levels of testosterone in plasma in rats with varicocele were lower than those in the sham-operated rats. The concentration of testosterone in the left testis was lower than that in the right testis in varicocele-induced rats while no such differences were observed in sham-operated rats. The seminiferous tubular diameter in the left testis is reduced in varicocele-induced rats from that in the right testis. In the sham animals, testicular acid phosphatase activity was higher in the left testis than the right, while in varicocele-induced animals, no differences in acid phosphatase activity between left and right testis were observed. In varicocele-created rats, the activity of alkaline phosphatase was higher in the left testis than in the right while no differences in alkaline phosphatase activity between left and right testis in sham-operated rats were observed.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究旨在确定手术诱导的精索静脉曲张对成年诺布尔大鼠睾丸雄激素生成、生精小管直径以及睾丸和附属生殖器官中酸性和碱性磷酸酶活性的影响。对假手术组和精索静脉曲张诱导组大鼠的血浆以及左右睾丸中的睾酮浓度进行了评估。对精索静脉曲张诱导组和假手术组大鼠的左右睾丸、精囊和腹侧前列腺中的酸性和碱性磷酸酶活性进行了测量。精索静脉曲张大鼠血浆中的睾酮水平低于假手术组大鼠。在精索静脉曲张诱导组大鼠中，左侧睾丸中的睾酮浓度低于右侧睾丸，而在假手术组大鼠中未观察到此类差异。精索静脉曲张诱导组大鼠左侧睾丸的生精小管直径比右侧减小。在假手术动物中，左侧睾丸的睾丸酸性磷酸酶活性高于右侧，而在精索静脉曲张诱导的动物中，未观察到左右睾丸酸性磷酸酶活性的差异。在制造了精索静脉曲张的大鼠中，左侧睾丸的碱性磷酸酶活性高于右侧，而在假手术组大鼠中未观察到左右睾丸碱性磷酸酶活性的差异。（摘要截于250字）
