Moerman C J, Berns M P, Bueno de Mesquita H B, Runia S
Department of Chronic Disease and Environmental Epidemiology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
Int J Cancer. 1994 Apr 15;57(2):146-53. doi: 10.1002/ijc.2910570203.
Although reproductive factors have been shown to be related to the composition of bile and functioning of the biliary system, their relationship with biliary tract cancer has not been studied in detail. Between 1984 and 1987 we conducted a case-control study of 75 women with cancer of the biliary tract and 252 controls from the general population. An interviewer-administered questionnaire was used to collect information on reproductive history. The information was obtained from the responders themselves (direct response) or from relatives (indirect response). Our results indicate that younger age at menarche, early age at first pregnancy, higher number of pregnancies and prolonged fertility may enhance the risk of cancer of the biliary tract. Overall, increased exposure to endogenous oestrogens and progesterone constitutes a higher risk.
尽管生殖因素已被证明与胆汁成分及胆道系统功能有关，但其与胆道癌的关系尚未得到详细研究。1984年至1987年间，我们对75例胆道癌女性患者和252名来自普通人群的对照者进行了一项病例对照研究。通过访谈者管理的问卷收集生殖史信息。这些信息从应答者本人（直接回答）或亲属（间接回答）处获得。我们的结果表明，初潮年龄较小、首次怀孕年龄较早、怀孕次数较多以及生育期延长可能会增加患胆道癌的风险。总体而言，内源性雌激素和孕激素暴露增加会构成更高的风险。
