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不同免疫球蛋白类别的抗体应答调节。IV. 从二硝基苯 - 分枝杆菌致敏T细胞释放的IgE类特异性“抑制因子”的特性和功能。

Regulation of antibody response in different immunoglobulin classes. IV. Properties and functions of IgE class-specific" suppressor factor(s) released from DNP-mycobacterium-primed T cells.

作者信息

Kishimoto T, Hirai Y, Suemura M, Nakanishi K, Yamamura Y

出版信息

J Immunol. 1978 Nov;121(5):2106-12.

PMID:81866
Abstract

IgE class-specific suppressor factors (IgE-TsF) released from DNP-Myc-primed T cells showed their suppressor effect in an antigen nonspecific manner, although DNP-specific stimulation was required for their induction. The suppressor activity of IgE-TsF was absorbed with the alloantiserum directed to the subregions between I-A and I-E of the H-2 complex. IgE-TsF from BALB/c mice did not show their suppressor effect on the IgE response of C57BL/6J and vice versa. The suppressor activity of IgE-TsF was removed with a DNP-OA-primed B lymphocyte population including an increased number of IgE-B cells, but not with T cells. Incubation of hapten-primed B cells with IgE-TsF for 3 hr at 37 degrees C selectively abolished the anti-hapten IgE antibody response in the adoptive transfer experiment, indicating that the target cells of IgE-TsF were IgE-B cells.

摘要

从二硝基苯-髓细胞瘤致敏的T细胞释放的IgE类特异性抑制因子（IgE-TsF），尽管其诱导需要二硝基苯特异性刺激，但其以抗原非特异性方式发挥抑制作用。IgE-TsF的抑制活性可被针对H-2复合体I-A和I-E之间亚区的同种抗血清吸收。来自BALB/c小鼠的IgE-TsF对C57BL/6J小鼠的IgE应答未显示出抑制作用，反之亦然。IgE-TsF的抑制活性可被包含数量增加的IgE-B细胞的二硝基苯-卵白蛋白致敏B淋巴细胞群体去除，但不能被T细胞去除。在过继转移实验中，将半抗原致敏的B细胞与IgE-TsF在37℃孵育3小时，可选择性地消除抗半抗原IgE抗体应答，表明IgE-TsF的靶细胞是IgE-B细胞。

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Immunology. 1981 Sep;44(1):41-50.
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The role of T cells in regulating immunoglobulin class and subclass.T细胞在调节免疫球蛋白类别和亚类中的作用。
Immunology. 1980 Nov;41(3):743-52.
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A clonal analysis of the IgE response and its implications with regard to isotope commitment.IgE 应答的克隆分析及其与同种型定向的关系
J Exp Med. 1981 Apr 1;153(4):783-92. doi: 10.1084/jem.153.4.783.
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Selective suppression of the major idiotypic component of an antihapten response by soluble T cell-derived factors with idiotypic or anti-idiotypic receptors.利用具有独特型或抗独特型受体的可溶性T细胞衍生因子选择性抑制抗半抗原反应的主要独特型成分。
J Exp Med. 1980 May 1;151(5):1213-31. doi: 10.1084/jem.151.5.1213.
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Recent studies on the regulation of IgE antibody synthesis in experimental animals and man.近期关于实验动物和人类中IgE抗体合成调控的研究。
Immunology. 1980 Sep;41(1):1-24.
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Identification of soluble Fc receptors in mouse serum and the conditioned medium of stimulated B cells.小鼠血清及刺激B细胞条件培养基中可溶性Fc受体的鉴定。
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Surv Immunol Res. 1982;1(1):17-23. doi: 10.1007/BF02918237.
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