Ohshima K, Yoshitake K, Ugaeri H, Kikuchi M, Yoneda S
First Department of Pathology, School of Medicine, Fukuoka University, Japan.
Virchows Arch. 1994;424(3):327-30. doi: 10.1007/BF00194619.
A 63-year-old man with malignant histiocytosis of the intestine died 3 days after gastrectomy for early gastric adenocarcinoma. Malignant histiocytosis of the intestine was unexpectedly found at autopsy. The intestine was thickened with mucosal erosions. Histologically, a few atypical large histiocyte-like cells were found in focal aggregates in the mucosa. These large cells expressed the T-cell antigen and monoclonality was demonstrated by the polymerase chain reaction showing variable-joining segment rearrangement in the T-cell receptor delta-chain gene. Malignant histiocytosis of the intestine was thus diagnosed.
一名63岁男性因早期胃腺癌接受胃切除术后3天死于肠道恶性组织细胞增多症。尸检时意外发现肠道恶性组织细胞增多症。肠道增厚，伴有黏膜糜烂。组织学检查显示，黏膜中可见局灶性聚集的少数非典型大组织细胞样细胞。这些大细胞表达T细胞抗原，通过聚合酶链反应证明其单克隆性，显示T细胞受体δ链基因的可变连接区重排。由此诊断为肠道恶性组织细胞增多症。
