酵母第十一号染色体的完整DNA序列。

Complete DNA sequence of yeast chromosome XI.

作者信息

Dujon B, Alexandraki D, André B, Ansorge W, Baladron V, Ballesta J P, Banrevi A, Bolle P A, Bolotin-Fukuhara M, Bossier P, Bou G, Boyer J, Bultrago M J, Cheret G, Colleaux L, Dalgnan-Fornler B, del Rey F, Dlon C, Domdey H, Düsterhoft A, Düsterhus S, Entlan K D, Erfle H, Esteban P F, Feldmann H, Fernandes L, Robo G M, Fritz C, Fukuhara H, Gabel C, Gaillon L, Carcia-Cantalejo J M, Garcia-Ramirez J J, Gent N E, Ghazvini M, Goffeau A, Gonzaléz A, Grothues D, Guerreiro P, Hegemann J, Hewitt N, Hilger F, Hollenberg C P, Horaitis O, Indge K J, Jacquier A, James C M, Jauniaux C, Jimenez A, Keuchel H, Kirchrath L, Kleine K, Kötter P, Legrain P, Liebl S, Louis E J, Maia e Silva A, Marck C, Monnier A L, Möstl D, Müller S, Obermaier B, Oliver S G, Pallier C, Pascolo S, Pfeiffer F, Philippsen P, Planta R J, Pohl F M, Pohl T M, Pöhlmann R, Portetelle D, Purnelle B, Puzos V, Ramezani Rad M, Rasmussen S W, Remacha M, Revuelta J L, Richard G F, Rieger M, Rodrigues-Pousada C, Rose M, Rupp T, Santos M A, Schwager C, Sensen C, Skala J, Soares H, Sor F, Stegemann J, Tettelin H, Thierry A, Tzermia M, Urrestarazu L A, van Dyck L, Van Vliet-Reedijk J C, Valens M, Vandenbo M, Vilela C, Vissers S, von Wettstein D, Voss H, Wiemann S, Xu G, Zimmermann J, Haasemann M, Becker I, Mewes H W

机构信息

Unité de Génétique Moléculaire des Levures (URA 1149 du CNRS and UFR927 University P.M. Curie), Départment de Biologie Moléculaire, Insitut Pasteur, Paris, France.

出版信息

Nature. 1994 Jun 2;369(6479):371-8. doi: 10.1038/369371a0.

DOI:10.1038/369371a0

PMID:8196765

Abstract

The complete DNA sequence of the yeast Saccharomyces cerevisiae chromosome XI has been determined. In addition to a compact arrangement of potential protein coding sequences, the 666,448-base-pair sequence has revealed general chromosome patterns; in particular, alternating regional variations in average base composition correlate with variations in local gene density along the chromosome. Significant discrepancies with the previously published genetic map demonstrate the need for using independent physical mapping criteria.

摘要

已测定出酿酒酵母第十一染色体的完整DNA序列。除了潜在蛋白质编码序列的紧密排列外，这条666,448个碱基对的序列还揭示了一般的染色体模式；特别是，平均碱基组成的交替区域变化与沿染色体的局部基因密度变化相关。与先前发表的遗传图谱存在显著差异，这表明需要使用独立的物理图谱标准。